Mart Saarma Selected Research

Nerve Growth Factors (Neurotrophins)

5/2022	The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte-Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity.
2/2022	CDNF and MANF regulate ER stress in a tissue-specific manner.
1/2022	Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism.
1/2021	Neurotrophic Factors in Parkinson's Disease: Clinical Trials, Open Challenges and Nanoparticle-Mediated Delivery to the Brain.
10/2020	Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic science and clinical studies.
1/2020	Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice.
11/2019	Levels of glial cell line-derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson's disease.
1/2019	Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function.
1/2019	Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy.
1/2019	Increased Serum Levels of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Subjects With Parkinson's Disease.

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Mart Saarma Research Topics

Disease

41	Parkinson Disease (Parkinson's Disease) 01/2021 - 02/2007
10	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2022 - 04/2010
3	Alzheimer Disease (Alzheimer's Disease) 09/2020 - 09/2015
3	Multiple Endocrine Neoplasia Type 2b (MEN 3) 08/2011 - 05/2007
2	Stroke (Strokes) 05/2022 - 01/2014
2	Nervous System Diseases (Neurological Disorders) 01/2021 - 04/2016
2	Retinal Degeneration 12/2020 - 09/2020
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 09/2020 - 02/2007
2	Neuralgia (Stump Neuralgia) 09/2020 - 01/2017
2	Infarction (Infarctions) 01/2014 - 07/2009
2	Neoplasms (Cancer) 07/2009 - 05/2007
1	Ischemic Stroke 05/2022
1	Proteostasis Deficiencies 01/2022
1	Overnutrition 01/2022
1	Obesity 01/2022
1	Body Weight (Weight, Body) 01/2022
1	Weight Gain 01/2022
1	Synucleinopathies 01/2021
1	Wolfram Syndrome (Syndrome, Wolfram) 12/2020
1	Diabetes Mellitus 12/2020
1	Multiple Endocrine Neoplasia Type 2a (MEN 2) 02/2020
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2020
1	Cognitive Dysfunction 11/2019
1	Enterocolitis 01/2019
1	Hirschsprung Disease (Hirschsprung's Disease) 01/2019
1	Brain Diseases (Brain Disorder) 08/2018
1	Hyperalgesia 01/2018
1	Hypersensitivity (Allergy) 01/2017
1	Mental Disorders (Mental Disorder) 01/2017
1	Neuroinflammatory Diseases 04/2016
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2016
1	Leukemia 01/2016
1	Inflammation (Inflammations) 12/2014
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2014
1	Ischemia 01/2014
1	Acquired Immunodeficiency Syndrome (AIDS) 02/2013
1	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2009
1	Spinal Cord Injuries (Spinal Cord Injury) 12/2009
1	Necrosis 07/2009
1	Brain Ischemia (Cerebral Ischemia) 07/2009
1	Brain Injuries (Brain Injury) 07/2009
1	Status Epilepticus (Complex Partial Status Epilepticus) 11/2008

Drug/Important Bio-Agent (IBA)

26	Nerve Growth Factors (Neurotrophins)IBA 05/2022 - 07/2009
26	Dopamine (Intropin)FDA LinkGeneric 05/2022 - 02/2007
21	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 01/2022 - 02/2007
9	Oxidopamine (6 Hydroxydopamine)IBA 11/2020 - 07/2007
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2007
6	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2022 - 01/2019
4	Messenger RNA (mRNA)IBA 07/2009 - 04/2005
3	NeurturinIBA 01/2019 - 02/2007
3	Glial Cell Line-Derived Neurotrophic Factors (GDNF Family Ligands)IBA 01/2019 - 01/2011
3	Neuroprotective AgentsIBA 01/2016 - 07/2009
3	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 08/2011 - 05/2007
2	SynucleinsIBA 01/2021 - 01/2017
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2017 - 06/2008
2	Therapeutic UsesIBA 01/2016 - 09/2015
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2012 - 08/2011
1	Appetite Depressants (Anorectics)IBA 01/2022
1	Matrix Metalloproteinases (MMPs)IBA 01/2022
1	Growth Differentiation Factor 15IBA 01/2022
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 01/2022
1	Netrin-1IBA 01/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	DCC ReceptorIBA 01/2021
1	Cell Surface ReceptorsIBA 12/2020
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 02/2020
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 11/2019
1	Becaplermin (PDGF-BB)FDA Link 01/2019
1	MucinsIBA 01/2019
1	Platelet-Derived Growth FactorIBA 01/2019
1	Biological ProductsIBA 08/2018
1	Opioid Analgesics (Opioids)IBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018
1	Morphine (MS Contin)FDA LinkGeneric 01/2018
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 04/2016
1	NeuropeptidesIBA 04/2016
1	Phosphotransferases (Kinase)IBA 01/2016
1	Proteasome InhibitorsIBA 12/2015
1	lactacystinIBA 12/2015
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2014
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2014
1	LigandsIBA 01/2014
1	Dietary ProteinsIBA 01/2014
1	Chemotactic FactorsIBA 01/2014
1	Amphetamine (Amfetamine)FDA LinkGeneric 08/2011
1	NeurotoxinsIBA 08/2011
1	persephinIBA 07/2010
1	Thyroid HormonesIBA 12/2009
1	Heparin (Liquaemin)FDA LinkGeneric 10/2009
1	Arginine (L-Arginine)FDA Link 07/2009
1	triphenyltetrazoliumIBA 07/2009
1	alpha-Methyltyrosine (Metirosine)FDA Link 06/2008
1	Tetrabenazine (Nitoman)FDA Link 06/2008
1	Dopamine Agonists (Dopamine Agonist)IBA 05/2008

Therapy/Procedure

5	Therapeutics 05/2022 - 08/2018
1	Deep Brain Stimulation 01/2018
1	Ligation 01/2017
1	Vascular Surgical Procedures 01/2014
1	Protein-Restricted Diet (Diet, Protein Restricted) 01/2014
1	Diet Therapy (Therapy, Diet) 01/2014